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2018-01-23 13:07:32
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Approximately 30%-40% of inhaled lead is absorbed into the blood stream[2]. Gastrointestinal absorption varies depending on nutritional status and age. Iron is believed to impair lead uptake in the gut, while iron deficiency is associated with increased blood lead concentrations in children. Once absorbed, 99% of circulating lead is bound to erythrocytes for approximately 30-35 d (only 1% of absorbed lead is found in plasma and serum) and is dispersed into the soft tissues of liver, renal cortex, aorta, brain, lungs, spleen, teeth, and bones in the following 4-6 wk. The clinical manifestations can vary from individual to individual. Diagnosis of lead toxicity is mainly based on the elevated blood lead levels (BLL). There is a general correlation between toxic effects of lead and BLL. New data implicate that lower blood lead levels, previously considered normal, can cause cognitive dysfunction, neurobehavioral disorders, different neurological damages, hypertension and renal impairment[3–6].
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708379/
소화기를 통한 흡수율은 뭘먹었는지 등에 따라서 개인차가 있고 흡수된 납은 30-45일간 적혈구에 붙어있다가 다른 조직으로 이동하여 다양한 영향을 끼칠 수 있다고 하네요.